產(chǎn)品詳情介紹
HLA-DR是由36 kDa α鏈和27 kDa β鏈組成的異二聚體，由6號染色體短臂的MHC基因復(fù)合物編碼。兩條鏈可由許多不同的等位變異形態(tài)出現(xiàn)，存在高度的多態(tài)性。HLA-DR結(jié)構(gòu)性表達(dá)在抗原遞呈細(xì)胞上，主要表達(dá)于免疫系統(tǒng)的細(xì)胞[1]。HLA-DR在單核細(xì)胞上強表達(dá)，尤其是CD14＋CD16＋亞群[2]；在巨噬細(xì)胞、粒細(xì)胞、漿樣樹突狀細(xì)胞、小膠質(zhì)細(xì)胞、郎格漢斯細(xì)胞上亦可表達(dá)[1,3,4]。HLA-DR還可表達(dá)于一些造血細(xì)胞的幼稚階段，例如BFU-E，但不表達(dá)在CFU-E或原紅細(xì)胞[5]。本產(chǎn)品為小鼠抗人HLA-DR單克隆抗體，用于IF和FC方法特異性檢測人HLA-DR蛋白。
CD系列產(chǎn)品介紹視頻
[1] Ting JP, TROWSDALE J. Genetic control of MHC class II expression [J]. Cell. 2002, 109 Suppl: S21-33.
[2] Passlick B, Flieger D, Ziegler-Heitbrock HW. Identification and characterization of a novel monocyte subpopulation in human peripheral blood [J]. Blood. 1989, 74(7): 2527-34.
[3] Mattiace LA, Davies P, Dickson DW. Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors [J]. Am J Pathol. 1990, 136(5): 1101-14.
[4] Angel CE, George E, Ostrovsky LL, et al. Comprehensive analysis of MHC-II expression in healthy human skin [J]. Immunol Cell Biol. 2007, 85(5): 363-9.
[5] Nakahata T, Okumura N. Cell surface antigen expression in human erythroid progenitors:erythroid and megakaryocytic markers [J]. Leuk Lymphoma. 1994, 13(5-6): 401-9.
